These drugs possess central nervous depressant activity and consumers should be warned not to take these drugs when driving motor vehicles or operating machinery, or when taking sedatives, tranquilizers, or alcohol.
Retinal atrophy and corneal opacity have been observed in chronic toxicity studies in the rat.
Having depression and psychiatric problems puts you at higher risk of suicide.
Nevertheless, the drug should not be withheld because of pregnancy, but excessive use should be avoided.
Some of the mothers were taking multiple medications during their pregnancies.